Estrogen plus Progestin

NEJM — Effects of Estrogen plus Progestin on Health-Related Quality of Life In this trial in postmenopausal women, estrogen plus progestin did not have a clinically meaningful effect on health-related quality of life.

Not only did the WHI demonstrate that there may be health risks of these combinations, this paper (pre-published online – to appear in print on 5/8/03) demonstrates that they don't do much good for quality of life either.